Acid Exposure Induces Multiplication of Salmonella enterica Serovar Typhi
نویسندگان
چکیده
منابع مشابه
Acid exposure induces multiplication of Salmonella enterica serovar Typhi.
Salmonella enterica serovar Typhi faces several environmental stresses while going through the stomach (acidic pH) to the small intestine (basic pH) and intracellularly in macrophages (acidic pH) in humans. The acidic pH followed by alkaline pH in the small intestine might be responsible for expression of certain stress-induced genes, resulting in not only better survival but also induction of ...
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Objective(s):Typhoid fever is a dreadful disease of a major threat to public health in developing countries. Vaccination with bacterial immunodominant components such as surface proteins may prove as a potent alternative to live attenuated vaccines. InvH, an important part of needle complex in type three secretion system (TTSS) plays important role in efficient bacterial adherence and entry int...
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Results Forty representative S. Typhi strains belonged to 4 sequence types (ST1, ST2, ST890, and ST892). The predominant S. Typhi genotype (31/40) was ST2 and it had a diverse geographic distribution. We discovered two novel STs – ST890 and ST892. M-CGH showed that 69 genes in these two novel STs were divergent from S. Typhi Ty2, which belongs to ST1. In addition, 5 representative Typhi strains...
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The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ~5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal...
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Nepal is having a series of enteric fever epidemics over the last decade1,2 with changing resistance patterns.3 The fi rst report of multidrug resistant Salmonella enterica serovar Typhi in Nepal was published in 1991.4 In the following years, with the introduction of fl uoroquinolones in the treatment, nalidixic acid-resistant strains associated with reduced susceptibility to fl oroquinolones ...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2014
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.02275-14